Your Brain on Drugs: Marijuana

By Brian Lemay 100 comments

For centuries, humans have been using substances
to alter their state of mind. From caffeine, cigarettes and alcohol
to more extreme drugs. But as the most commonly used
illicit drug in North America, Where does marijuana fit in and how exactly does it affect your brain? First, we need to understand how the brain functions. Neurons are the cells that
process information in the brain. By releasing chemicals called neurotransmitters from the axon of one neuron
to the dendrite of another they change the electrical charge
of the receiving neuron consequently exciting or inhibiting it. If excited, the signal is passed on. Though it sounds simple
these signals work together and the effect is quickly compouned
into complex configurations within milliseconds flashing over the entire brain. This is what happens every single time
you think, breathe or move. So what is going on inside your brain
when you’re smoking marijuana? Well unlike alcohol, which contains molecules
nothing like those in our body, cannabis contains molecules that resemble those
produced in our very own brains: cannabonoids. Although naturally these cannabonoids
circulate at much lower quantities compared to the large influx imposed by smoking, specifically the chemical tetrahydrocannabinol or THC resembles a natural transmitter called “anandamide”. These cannabonoids are specialized neurotransmitters released by neurons having just fired. Neurons temporarily become unresponsive after firing to prevent them from overracting
or being too dominant. This allows your brain to function in a
calm and controlled manner. But cannabonoids interrupt this approach
in some parts of the brain. Instead, they remove the refractory period of neurons
that are already active and can cause your thoughts, imagination,
and perception to utterly magnify itself. This means, once you begin your train of thought it becomes the most significant
and profound thing ever. You can’t see the big picture
or even recall your last epiphany because you’re caught up in the momentum
of a particular idea and your neurons keep firing until a new idea takes hold
and you go off on a new tangent. These cannabonoids also affect the levels
of dopamine and norepinephrine in your brain often leading to a sense of euphoria,
relaxation, pain modulation and general enhancement of an experience, though sometimes causing anxiety. Furthermore, there are cannabonoid receptors in areas controlling short-term memory,
learning, coordination, movement control and higher cognitive functions. Got a burning question you want answered? Ask them in the comments
or on Facebook and Twitter and subscribe for more weekly science videos.


Unknown Account

Sep 9, 2019, 3:25 am Reply

Does anyone know what acis is and what the mg is like for edibles it’s weed and for acid it is

Don’t Sub To Me

Sep 9, 2019, 1:50 pm Reply

Im high af rn. Took me a minute to type the title of the video even this very own comment. I never felt so happy!

Ashy Slashy

Sep 9, 2019, 8:38 am Reply

Fuckin High

Ethan Lane

Sep 9, 2019, 8:39 pm Reply

Your brain on Marry Jane.


Sep 9, 2019, 4:36 am Reply

I love this video when I’m high 🙂


Sep 9, 2019, 9:01 pm Reply

Last night, as a muslim, I tried weed and I think i’m in love with my stonerself

Katharine Lowen

Sep 9, 2019, 8:14 pm Reply

When I smoke I just get full blown anxiety and I think I’m in a another universe sorry guys but I hate the feeling pot gives me 😔

Derick Bucknam

Sep 9, 2019, 6:09 pm Reply

Y is it some people can solve a Rubiks cube and most cant ?


Sep 9, 2019, 10:50 pm Reply

Finally something positive thanks!!!

Solid Karnage

Sep 9, 2019, 10:37 am Reply

i drank 6 energy cans a day whilst smoking more weed that my body could handle and ive been suffering from heart palpitations im only 18 but it was worth it i cant smoke weed ever again 🙁

Nathan Tonner-Barlog

Sep 9, 2019, 7:52 pm Reply

Don't smoke weed and get out of here!


Sep 9, 2019, 2:55 am Reply

I feel at Nirvana rn lol. You see so I have a wax pen and I am a pretty experimental type guy, really! I'm like a mad scientist or something, or just a fool 🙁 BUT I wanted to test some effects on Marijuana on the right side of my brain. How so? Simple by being weird and being a lil brave and so I held the button down and snorted a little of the marijuana through the right nostril while being under a lot of stress. The reason I'm here is because it worked lol! So the area of pain in my brain was in the right side and now I just wanted to see wtf my right brain was doing now lol cause its like floating in space rn. Sorry be back soon friends!

Free T

Sep 9, 2019, 5:11 am Reply

So true I had the best idea one time about a business when I was high and I can’t remember it to this day but I remember having a good idea. It kind of pisses me off this was a good idea

Marcos Blanco

Sep 9, 2019, 1:37 pm Reply

Im high af

pragya mishra

Sep 9, 2019, 7:22 pm Reply

Can you do a video on it's harmful or useful effect.

paul leepoy

Sep 9, 2019, 12:23 am Reply


Safi Rouhi

Sep 9, 2019, 7:14 am Reply

Based on this channels name they’re pretty forthcoming about how terrible their work is

Steven McCormac

Sep 9, 2019, 4:54 pm Reply

what’s happens to your stomach with smoking weed

Kamlesh Patel

Sep 9, 2019, 12:03 am Reply

Drugs are bad ,

Mike Bertelsen

Sep 9, 2019, 10:46 am Reply

High AS and I don't get anything he said. But I saw yellow chickens and small ant like things

Starseed Healer

Sep 9, 2019, 2:16 pm Reply

First time I smoked I was tripping balls felt like I dropped acid I feel like I dropped acid every time I smoke

drummerboy 76′

Sep 9, 2019, 5:49 pm Reply

I don't bash Marijuana but I do bash users of Marijuana. They tend to have tattoos, be lazy as heck, and smell bad most of the time. Which are qualities that I hate. And also, they talk about relaxation but when I smoked Marijuana for the last time in 2016, I was feeling panicky. I was seeing double and my heart was beating rapidly. It's strange but I do think that Marijuana should be in every single health care/medicine facility in America for medical reasons.

Daan D

Sep 9, 2019, 11:36 am Reply



Sep 9, 2019, 10:35 pm Reply

i have smoked hasjis for 35 years and have never been sick….not even a tiny cold.. is that normal?

veer Kullar

Sep 9, 2019, 8:41 pm Reply

So is it bad for you

Whit Yerkes

Sep 9, 2019, 9:00 pm Reply

im high

sumesh soman

Sep 9, 2019, 7:36 pm Reply

marijuana is not a drug idiot!

Incognito Rain

Sep 9, 2019, 10:18 pm Reply

gonna go ahead and smoke me some cunnahbis

Noomie Lifestyle

Sep 9, 2019, 1:01 pm Reply

thank you ASAP science for giving me inspirations for my english project 🙌🏻, totally watched the video multiple times to write down facts for the report🙃

Pumpy Lumpy

Sep 9, 2019, 8:31 pm Reply

Why u always lying

Weed is Great

Sep 9, 2019, 4:31 am Reply

When ur high and focused on the gaming music

Nikola Tesla

Sep 9, 2019, 10:07 am Reply

Can you, theoretically, use "clean" canabinoind to enchant your memory? Or these processes are completely different?

amr elgindy

Sep 9, 2019, 3:03 am Reply

High I’m hi

Gustavo Borges

Sep 9, 2019, 3:57 am Reply

Why this or the video it is so short like this ?


Sep 9, 2019, 12:42 pm Reply

Simple solution. Just legalize it man.

The Ziggy Aplin Show

Sep 9, 2019, 2:55 am Reply


linn linn

Sep 9, 2019, 10:05 am Reply

ျမန္မာလုိ မႈတ္

Aidan Pratz

Sep 9, 2019, 4:28 am Reply

Yet alcohol is legal

FTB Franky

Sep 9, 2019, 12:32 pm Reply

There was way too many Mine and Rine in da video for me😂😂😭

Yahshs Hshsjsdkdodi

Sep 9, 2019, 3:16 pm Reply

Can you do one on CBD hemp please.

Zimbra Fan

Oct 10, 2019, 1:07 am Reply

do you have your passports?


Oct 10, 2019, 1:39 pm Reply

1 time got super high i acted all slow mo.


Oct 10, 2019, 2:53 pm Reply

Have you ever watched ‘Saw’ while you were high? Literally any of the movies are a severe cringefest. Oh my god, it hurts so much. You can feel literally everything as if it was happening to you. But it’s such a fun experience, you get to live a little.

Salvation Salvatoré

Oct 10, 2019, 1:06 am Reply

If I ever do drugs, I’ll keep a log of my trips.

Rayan Hassan

Oct 10, 2019, 6:17 am Reply

How do does chemicals from a simple plant make you act differently from the norms of society?

•Min Kristina•

Oct 10, 2019, 6:12 pm Reply

First time i smoked weed was about 2 years ago.I had a really really bad trip beacuse i didn't know it was leaked.To this day i still don't know with what it was laked.I hit 2 times and keep it about 15 seconds and then i turn left and i my view was literally paused,i didn't feel my arms and legs and almost started crying beacuse i had really bad tripsitters who were laughting at me.They are not my friends anymore and thats the only good thing i learned from that trip.Does anyone one knows with what was it leaked?

Lelethu Lexy

Oct 10, 2019, 9:51 am Reply

I'm watching this while I'm smoking weed

Andrej Černe

Oct 10, 2019, 10:22 pm Reply

Watching this high lol

Maris Baier

Oct 10, 2019, 10:34 pm Reply

I'm mentally and maybe even physically on the moon right now


Oct 10, 2019, 8:34 am Reply


Adrián Basque

Oct 10, 2019, 5:31 pm Reply

im high im high im high, hi guys


Oct 10, 2019, 12:37 pm Reply

First time I smoked weed it felt like im dying

Aleksandra Olegova

Oct 10, 2019, 5:40 pm Reply

Hi I’m high

NX Cypher

Oct 10, 2019, 2:45 am Reply

Bro first time i got high i was scared of everything then that made me even more scared😂😂


Oct 10, 2019, 2:08 pm Reply

drug maximum ear wax with right nose hole

Jo V

Oct 10, 2019, 2:21 pm Reply

The reason you don't dream while you are using cannabis is because of excess noreanephrine because when you dream your brain neurons block the production of noreanephrine which causes your body to relax..

cool pfp but

Oct 10, 2019, 4:56 pm Reply

I got so much anxiety from smoking once i felt like i was shitting my pants in front of everyone and hid in the bathroom the rest of the night. Same thing happened another time except I thought i pissed myself but it wasnt as bad


Oct 10, 2019, 5:40 am Reply

who else high asf rn


Oct 10, 2019, 4:07 pm Reply

This video is a bit too glorifying, at least show the bad sides too like bad trips or memory loss

Yank ee

Oct 10, 2019, 9:08 pm Reply

If you're looking for intelligent comments, you've come to the wrong forum. This one has posted over its door 'All Moronic, Infantile, Druggie Assholes Welcome to Weigh In Here'.

Cookie Cat

Oct 10, 2019, 2:52 pm Reply


Cyka Blyat

Oct 10, 2019, 5:23 am Reply

I am so stoned now I am high school student but I cant go to school rn because Im too stoned so I'm gonna sleep rn

Aidan burleson

Oct 10, 2019, 7:20 am Reply

I'm so high I had to watch it 3 times

jose aguilar

Oct 10, 2019, 7:30 pm Reply

Im soooooo hiiiiiigggghh

Kyle Smith

Oct 10, 2019, 12:56 am Reply

Lol this was interesting to watch though

Kyle Smith

Oct 10, 2019, 12:59 am Reply

I dont remember my first time unfortunately though

David Romo

Oct 10, 2019, 2:02 pm Reply

Can cannibnolds stay in the brain forever

Thr is no name Ded

Oct 10, 2019, 6:36 pm Reply

I watched this while I was high ahaha

Raphaël Zajac

Oct 10, 2019, 11:18 pm Reply

Is There any product that makes you thinking more and more deeply but without giving you dopamine ? (so less addictive)

Gustave Bacareza

Oct 10, 2019, 1:48 pm Reply

What bond is THC… For my project

Leah Groves

Oct 10, 2019, 9:51 pm Reply


Leah Groves

Oct 10, 2019, 9:53 pm Reply

so it’s not that bad then


Oct 10, 2019, 10:44 pm Reply

I was so high today it’s not even funny I was sitting their laughing at a picture of a dna strand in the middle of class


Oct 10, 2019, 11:12 pm Reply

last time I smoked weed I was sent to the er because I shoved 3 screws up my rectum, in recollection, not a good call because I can't pee normal no more but felt good during the time

Pablo B.

Nov 11, 2019, 5:15 am Reply

I'm high as hell watching this video 😂😂

Tien Truong

Nov 11, 2019, 8:53 am Reply

Help me to know more clearly about drug lol

Tommaso Friz

Nov 11, 2019, 9:50 pm Reply

I’ve been bowling the wrong shit

Nov 11, 2019, 8:25 am Reply

Easily only about 5% of the people commenting they’ve smoked before actually have.

Tony Mudau

Nov 11, 2019, 4:38 pm Reply

Can weed cause alzheimers and eventually dementia?

Anthony Firlotte

Nov 11, 2019, 12:45 am Reply

English please?

kyle johnson

Nov 11, 2019, 11:04 pm Reply


Stoned Bjtch

Nov 11, 2019, 5:50 am Reply

so stoned rn what

Jeezy Carry

Nov 11, 2019, 8:06 pm Reply

Omfg the start of this vid… listing alcohol as a not extreme drug. Bullshit.

justin gromofsky

Nov 11, 2019, 11:39 pm Reply

I been smoking weed all my life does it cause memorie loss🌿🍀💨🙊

PierLuigi Murillo

Nov 11, 2019, 6:57 am Reply

That's why I love weed.

Emanuel Irimia

Nov 11, 2019, 10:05 pm Reply

my clothes on weed :


Nov 11, 2019, 2:56 am Reply

Any sober writers/authors just doing research?

Mr Johnny La Bamba

Nov 11, 2019, 6:28 pm Reply

0.87% THC in the state the flower is in, the rest of the THC is at that point THCa, a carboxylic acid group is attached to the THC molecule. What this means if you were to just eat that bud, only 0.87% of it is psychoactive in that state.

Upon decarboxilation, usually via heat, that group is stripped off the rest of the molecules and if conversion of every molecule of THCa to THC were to happen, then it would have accounted for 18.9% of the original mass.

For a vast majority of people the Total THC is the relevant number, and the other can be ignored. In some US states they make it even more confusion by doing a listing of THC, THCa and Total THC, and since THCa weighs more than THC people get very confused that the THC + THCa doesn't equal total THC.

Andrei 895

Nov 11, 2019, 10:00 pm Reply

One thing to know is that marijuana really doesn't help you through school and it does kinda make you dumb. Not really dumb, but it makes it harder to think when you're sober. Oh, and when you quit after a long period of smoking regularly, you'll get depression. It's really not a wonder of a drug imo. I would only smoke occasionally with friends.

Nautica Marie

Nov 11, 2019, 5:12 am Reply

I’m so high I watched this twice 🤣🤣

Justin Y.

Nov 11, 2019, 11:02 pm Reply

All of the 12 year olds claiming to be stoners


Nov 11, 2019, 11:57 pm Reply

Who’s high will scrolling threw the comments while ignoring the video?

America First

Nov 11, 2019, 6:33 am Reply

I smoke close to 8 pounds a yr , I clearly grow to support my habit , tbh I didn't get anything from this video …plz tell me what I missed

Big pump

Nov 11, 2019, 4:43 pm Reply

I go to school high asf everyday 😂

Cailum Collins

Nov 11, 2019, 4:58 pm Reply

Where my stoner gang at


Nov 11, 2019, 10:55 pm Reply

Ill just stick to my crack


Nov 11, 2019, 1:46 am Reply

Just keep tokin' and learnin' . Lots of love for you all

Amy Helsabeck

Nov 11, 2019, 1:57 am Reply

The new opiate craze…


Nov 11, 2019, 10:04 am Reply

My brain right now 😁

Sean Maxwell

Nov 11, 2019, 12:03 pm Reply

[email protected] is the plug you can trust to always deliver. Telegram: Sean Maxwell . Whatsapp: +1(407)9067905.

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