Your Brain On Coffee

By Brian Lemay 100 comments

With it’s stimulating effects, it’s easy
to understand why coffee is the second most traded commodity on Earth after oil. For many,
it keeps us awake and moving through our busy days. But how does it work? What exactly does
coffee do to your brain? Whenever you’re awake, a chemical called
adenosine slowly accumulates in your brain. And this adenosine binds to receptors which
slow down brain activity – ultimately, the more adenosine there is, the more tired your
brain feels. Which makes sense, as the longer you’re awake, the more fatigued you become.
Conversely, while you sleep, the concentration of adenosine declines, gradually promoting
wakefulness. But it turns out that the caffeine in your
coffee is incredibly similar to adenosine in structure. The caffeine works it’s way
through your bloodstream and into the brain, where it starts to compete and binds with
adenosine receptors. But because it’s not adenosine, the ‘sleepiness’ effect isn’t
felt. Adenosine can no longer bind, meaning it’s calming properties are diminished.
Which is great for you when you’re feeling tired! However, with long term use of caffeine,
your brain responds by creating more adenosine receptors – which means more caffeine is required
to elicit the same response. It also means that when you try to quit drinking coffee
or miss your daily intake, you might experience some withdrawal symptoms and feel more tired
than you would have before you ever drank coffee! But the caffeine doesn’t stop there! It
also stimulates the production of adrenaline – you know, the Fight or Flight hormone? This
increases your heart rate, gets your blood pumping, and even opens up your airways. Furthermore,
it affects Dopamine levels by preventing its reabsorption in the brain, which makes you
feel happy! In fact, this is the exact same thing that cocaine does, just to a lesser
degree. It’s a drug, afterall! This dopamine stimulation is also the aspect of coffee that
makes it moderately addictive. So can you drink too much coffee? It turns
out there is a lethal dose of caffeine which is somewhere around 150mg of caffeine per
kilogram of your body. This means if you weigh 70kg you would require 14,000mg of caffeine
to overdose. Put into perspective, an average cup of coffee contains roughly 150mg of caffeine,
meaning if you are 70kg, approximately 70 cups of coffee would kill you. However, you’d
have to drink those cups all at once making it effectively impossible to overdose on caffeine
from coffee, since you wouldn’t be able to physically fit that much in your stomach.
You’d also start experiencing mania and hallucinations before getting to this point. Caffeine also has a halflife of around 6 hours
-so if you drank a standard coffee with around 150mg of caffeine, after about 6 hours there
will only be 75mg left in your system and you’ll be feeling half of the effect. And
6 hours after that, you’ll have 37.5mg – leaving more room for adenosine to jump back into
action. Which is why you may reach for another cup throughout the day, to maintain that glorious,
alert and energetic feeling. So drink up! And enjoy the buzz…while it
lasts 🙂 And for all of you in school, while we know
caffeine is key, so are good deals on textbooks! So we’ve teamed up with to
get you the cheapest prices for the books you need. All you have to do is head to
and search the ISBN number of the books your looking for. SlugBooks will then compare prices
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this will save you some money! Special thanks to SlugBooks for supporting AsapSCIENCE. Got a burning question you want answered? Ask it in the comments or on Facebook or Twitter. And subscribe for more weekly science videos!


Channel Channel

May 5, 2019, 12:27 pm Reply

Caffeine addiction is a thing, trust me


May 5, 2019, 3:12 pm Reply

Coffee makes me hyper and it feels absolutely amazing.

rated r

May 5, 2019, 4:07 am Reply

Nice info bro…thanks

Caterina Christakos

May 5, 2019, 9:13 pm Reply

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May 5, 2019, 10:48 pm Reply

Coffee had no effect on me ever since the first time I tried it. But then you move on to bigger stuff that doesn't have that simple 150 mg, it has just about 750. Then you start feeling stuff, and then you get worried, because now 70 cups at once just wont kill. 10 in one day will, and isn't that interesting.

Makhi Crayton

May 5, 2019, 2:18 pm Reply


A Bone to Pick

May 5, 2019, 1:40 am Reply

False. Overdosing is using the amount of a drug at which adverse health affects appear. Overdosing happens long before lethal dose.

Fear3Cool FN

May 5, 2019, 3:36 pm Reply

The only good video I can find about coffee ☕️ Btw I love coffee ?? ❤️ ☕️


May 5, 2019, 7:07 pm Reply

i drink coffee with almond milk and i drink coffee like once a week so i guess i’m fine?…idk

maruxa cabaleiro saco

May 5, 2019, 8:09 pm Reply

I drink coffee in the mornig , afternoon and after dinner , even ,when I am too tired to sleep , I just have a cup of milk and coffee , and I sleep faster . I suppose I am a bit of an addict .

The Golden Dragon

May 5, 2019, 9:42 pm Reply

I drink 3 or 4 cups a day and I keep seeing things move slightly like I'm skitzo

DMT elf Ireland

May 5, 2019, 9:49 am Reply

I like to call it gogo juice or brown water


Jun 6, 2019, 4:49 pm Reply

hmmm if drinking much caffeine has the response of making more adenosine receptors do they also go away if you stop drinking caffeine?

Sogol Heydari

Jun 6, 2019, 9:29 pm Reply

how should we stop eating coffe ? 🙁 I can Not control myself? I am eating more than the day before 🙁


Jun 6, 2019, 11:03 pm Reply

My mom is kinda fidgety now


Jun 6, 2019, 12:38 am Reply

2:11 xD

why so serious ?

Jun 6, 2019, 5:51 am Reply

I Love Coffee!!


Jun 6, 2019, 11:03 am Reply

"long term use=creates more receptors"!ha.!! thats why i dont drink coffee

Samit Tuladhar

Jun 6, 2019, 10:06 am Reply

Anybody else watching this while sipping coffee? :v


Jun 6, 2019, 10:37 am Reply

is it me or does coffee make absolutely no difference on me?

Heulwen Rhosyn

Jun 6, 2019, 12:17 am Reply

"Slut books .com" ???

Sarah Abbott

Jun 6, 2019, 8:30 pm Reply

I had a full on panic attack earlier because I consumed 100g choc coffee beans and felt weird. I thought I overdosed and was one of my triggers for summer time depression.
I’m okay now… I forgot about the caffeine in the beans. Scary to say the least

Deceased Fatality

Jun 6, 2019, 6:41 am Reply

Coffee doesn’t make me feel anything

Jack Daniels

Jun 6, 2019, 3:14 pm Reply

I remember going to a friends house one night after work, and his brother and I were really into coke heavy at the time and I had drank the large cans of redbull before going into work, I made the mistake of doing about a gram and a half with them and we stayed up all night playing super smash bros melee till 5 a.m. and I was pacing back and forth around his living room because it felt like my heart was about to come out of my asshole. Needless to say I never touched a redbull again

Vicente Dagnino

Jun 6, 2019, 6:09 am Reply

Shit just makes a nigga sleepy oh who am I kidding I just want some weed ??

Rediet Telahune

Jun 6, 2019, 12:37 am Reply

The real question is: 1:37 is that cocain real?!


Jun 6, 2019, 12:35 pm Reply

just do a caffeine fast for One week and everything goes back to normal , i do this every month so i can experience the full benefits with 1-2 cups


Jun 6, 2019, 9:21 pm Reply

This is why I don't drink coffee

NoMouthPlayz Game

Jun 6, 2019, 9:42 pm Reply

That is why i cannot sleep

Darth Vader

Jun 6, 2019, 3:08 pm Reply

So if I drink too much coffee I will be the next Einstein?


Jun 6, 2019, 3:08 pm Reply

I’m scared for doing something like I’ve got a job (work experience) I have to do for a week, I’m scared of talking one on one with my worker, so if I drink coffee in the morning would it help me to Carm down or make me not scared to talk?

Good Bye

Jul 7, 2019, 2:18 am Reply

Who else watched this because they just woke up from a major caffeine crash

Weitter Kadenokouji

Jul 7, 2019, 1:32 pm Reply

I can drink plain coffee and I will still sleep like a baby. I wish coffee made me awake like the others

Andrew Kemp

Jul 7, 2019, 7:55 pm Reply

Coffee makes me jittery but tired at the same time


Jul 7, 2019, 10:53 am Reply

ai interesting thanks brother

Jay Lynn

Jul 7, 2019, 7:08 pm Reply

Watching this while on about 6-10 espresso ?‍♀️???

Old memes Are great

Jul 7, 2019, 10:15 am Reply

Is it bad that I just have a small craving for coffee after a year of drinking it?

Isaac Rivera

Jul 7, 2019, 11:13 am Reply

I love coffee ☕️


Jul 7, 2019, 3:24 am Reply

Man I love coffee

Leo Yang

Jul 7, 2019, 5:19 pm Reply

How does coffee give you headaches if you drink too much?


Jul 7, 2019, 4:38 pm Reply

coffee makes me sleepy

Dr. Love

Jul 7, 2019, 10:40 pm Reply

Legal drug!

KaoticFear #Kaotic

Jul 7, 2019, 1:08 am Reply

I feel nothing when I drink coffee I have to drink energy drinks

COK Til You Drop

Jul 7, 2019, 5:44 am Reply

I swear I thought he said slut books

Israel andersonHOME

Jul 7, 2019, 10:16 pm Reply

A few years back, I would always drink caffeinated soda, and I was really feeling the effects. One effect that overwhelmed all was anxiety. I constantly felt anxious. I decided enough is enough, and I went cold turkey. I cheated here and there, but eventually I quit. It is amazing how much better I feel now.

Rico loop

Jul 7, 2019, 12:35 pm Reply

It is only one legal drug that i can take..

Jennifer Corbett

Jul 7, 2019, 6:57 pm Reply

This video: Your Brain On Coffee
Tweek from South Park: THE EXPERT

Gene Lariv

Jul 7, 2019, 6:55 pm Reply

caffeine. no positives. depression. anxiety. insomnia.

ImAndrew 766

Jul 7, 2019, 5:28 am Reply

I drank my first coffee today oh there's one problem im 12 anddd idk if it's good for me should i stop?

JoyCon Boyz Forever

Aug 8, 2019, 4:09 am Reply

I feel nothing…


Aug 8, 2019, 9:54 pm Reply

I am coffee addict


Aug 8, 2019, 3:20 pm Reply

Any evidence that adenosine receptors normalize after quitting? How long?

Nash John

Aug 8, 2019, 2:20 am Reply

Sheldon Cooper brought me here

Görkem Türkay

Aug 8, 2019, 2:50 pm Reply

may i consume coffee by snorting? does it affect in the same way? probably faster


Aug 8, 2019, 6:43 pm Reply

How often can i drink coffee to not build resistance

Anything_goes Anything_happens

Aug 8, 2019, 8:00 pm Reply

Man I really have a bad caffeine addiction.

Wwe Fans

Aug 8, 2019, 4:09 pm Reply

Loose stools after drinking coffee

F-22 Raptor

Aug 8, 2019, 10:20 am Reply

Coffee has no effect on me and I drink it rarely.


Aug 8, 2019, 2:08 pm Reply

It's natural that means there are no chemicals lol

Anonymous Anonymous

Aug 8, 2019, 10:57 am Reply

me: drinks one decaf frappucino a week
my mom: oh nO yoU aRE aDDiCTEd!


Aug 8, 2019, 2:11 pm Reply

The other addictive substance mixed with coffee is sugar.
Remember to time your coffee's half-life to when you need to sleep.


Aug 8, 2019, 3:13 pm Reply

If I want to undo a caffeine tolerance, how long do I have to go without caffeine

n i b b a p e n i s g u a c a m o l e

Aug 8, 2019, 5:29 pm Reply

It makes me have anxiety… ?

Emily Zamora

Aug 8, 2019, 1:37 am Reply

Haaa poop ? not haaa


Aug 8, 2019, 3:59 am Reply

I do wish people would read and learn more. It's a psychoactive drug as well as a pesticide. It's a natural insecticide, covered in unnatural pesticides (unless it's organic) that can't be rinsed or boiled away.

Some people are sensitive to it. Others have high tolerance. Some have an allergy to it and don't know it. This video is incomplete. You can experience mania and even a long bout of psychosis with way less than 14000mg!!! And it's not just a handful of people. Have you seen these pre-workout powders with 350mg or more per dose? It's insane. Btw, I'm far from a coffee hater.

Toontown Captain Jacques

Aug 8, 2019, 1:53 pm Reply

I’m drinking coffee for the first time in a year
Why am I here now


Sep 9, 2019, 2:21 am Reply

Coffee is a drug

Nyan Cat

Sep 9, 2019, 9:29 pm Reply

I heard somewhere that caffeine can be just as addictive if not MORE addictive than nicotine..?


Sep 9, 2019, 11:08 pm Reply

Very interesting! No wonder coffee no longer hypes me but without it I'm super tired.

Larry Putra

Sep 9, 2019, 12:16 am Reply

I feel good at first when I consume coffee but later I feel very bad even though I take a small cup


Sep 9, 2019, 12:57 am Reply

Is drinking a cup of coffe every day makes me heart attack?

Priya Yadav

Sep 9, 2019, 3:20 pm Reply

Well, that was the video I needed to watch all along.

Y0ung_ C1an

Sep 9, 2019, 6:17 am Reply

Coffee isn't a drug It actually Helps u out throughout the Day yes U can sleep from it But it still helps you It's not a drug

Ryan Neville

Sep 9, 2019, 2:05 am Reply

Check your math…… 150*70=10,500. Not 14,000


Sep 9, 2019, 4:04 am Reply

Whenever I drink coffee it does nothing…so sad

GontaaGokuharaa Gokuhara

Sep 9, 2019, 1:36 pm Reply

Coffe makes me pee

Jianghao YouTube

Sep 9, 2019, 10:56 am Reply

I had a double Expresso and I feel bit weird


Oct 10, 2019, 6:00 pm Reply

Caffeine and THC is my favorite combo. Mental alertness meets chill moods and good times. Being high without being sloppy about it. That's what I like

Matt Boselli

Oct 10, 2019, 9:10 pm Reply

I don't know anybody else but when I drink coffee it comes we down it's supposed to make people wiry and jittery but does the opposite for me


Oct 10, 2019, 9:46 pm Reply

Coffee gives me anxiety but sometimes I can't resist the taste yet regret consuming it immediately when I start being emotional

mohammad nouri

Oct 10, 2019, 1:53 pm Reply

how can i get the subtitle ?

The Unseen

Oct 10, 2019, 4:56 pm Reply

So just drink 1 cup a day


Oct 10, 2019, 7:00 pm Reply

People who say drinking coffee makes you tired, have you actually watched the video? Coffee keeps you awake, it doesn’t give you energy, so if you don’t sleep, then you’re obviously tired, since there’s already too much adenosine.


Oct 10, 2019, 2:57 pm Reply

It taste so bad

Nelson Contreras

Oct 10, 2019, 5:35 pm Reply

I’m lit on caffeine

Nathan Tonner-Barlog

Oct 10, 2019, 5:52 pm Reply

Here's some caffeine-less herbal tea!
PS: Its healthy and not addictive!

Chris Baumann

Oct 10, 2019, 5:52 pm Reply

Coffee is NOT the second-most traded commodity in the world, not by volume, nor by worth. Please look it up and do away with this myth. Thx!

Sub Zer0

Oct 10, 2019, 12:50 pm Reply

Having coffee, a ciggarrete and a pint right now. I feel so good.

Matthew Family

Oct 10, 2019, 3:52 pm Reply

Caffeine makes my headaches go away

Ruby iscute

Oct 10, 2019, 4:38 pm Reply

I’m no mathematician, but 70×150 is not 14000


Oct 10, 2019, 5:10 pm Reply

Well I’m immune to any form of caffeine and o don’t like coffee

bri cheeze

Oct 10, 2019, 10:47 pm Reply

fookin lies

bri cheeze

Oct 10, 2019, 10:47 pm Reply

coffee is yommy

Supriya Sharma

Oct 10, 2019, 4:59 am Reply

Hey asap science… This is the best video on effects of coffee on brain.
Please do a video on is coffee good for u or bad. (well, u did partially answer the question when u equated coffee with cocaine!)

Io Maalo

Oct 10, 2019, 11:32 pm Reply

Thank you this helps

Lily of the Desert

Oct 10, 2019, 10:31 am Reply

1 gramm 1000mg can kill you if you are 100kg! What a load of bullshjitt! 1,5 gramms and its a certain death!

George Washington

Oct 10, 2019, 5:19 am Reply

Dumbass normies getting addicted to bean juice


Oct 10, 2019, 9:19 am Reply

What do you mean, while it lasts?


Nov 11, 2019, 5:06 pm Reply

In Soviet Russia coffee is on you


Nov 11, 2019, 6:57 pm Reply

1:57 math is worng

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